Event Registration

Modeling Human Immunobiology In Vivo: Replacing NHPs with Humanized Mice in Preclinical Antibody Testing

September 23, 2025, 4:30 PM CEST | 10:30 AM ET (New York)
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With increasing regulatory scrutiny and ethical concerns surrounding non-human primate (NHP) usage, JAX’s humanized mouse models provide a scientifically superior and cost-effective alternative, redefining preclinical antibody drug development. Attendees will learn how these models better recapitulate human physiology, the FcRn IgG recycling system, and functional human immune cell effectors, making them ideal for efficacy, safety, and PK studies.

In this webinar, we will explore:

  • The HuPK platform and its relevance for FcRn-mediated IgG recycling
  • Next-generation human immune system models for antibody testing
  • Regulatory trends favoring alternatives to NHPs
  • Case examples demonstrating improved predictive power of humanized mice over NHPs

This virtual event is complimentary.
No fees will be charged for registering.

Agenda & Presentation Details

Overview of Regulatory and Scientific Drivers and Introduction

Phil Gaskin, Ph.D.

Business Development Director

The Jackson Laboratory

HuPK Platform: Modeling Human FcRn for Better PK Predictions

Adriano Flora, Ph.D.

Business Development Director

The Jackson Laboratory

Next-Gen Immune-Humanized Models for Antibody Drug Development

Brian Soper, Ph.D.

Senior Scientific Engagement Manager

The Jackson Laboratory

Novel In Vitro and In Vivo Strategies for the Evaluation of Antibody-Drug Conjugates for Oncology

Lenka Sadilkova, Ph.D.

Director Non-clinical Projects

Mablink Bioscience - Eli Lilly

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1.800.422.6423 (USA) | 1.207.288.5825 (International)
1.800.422.6423 (USA)
1.207.288.5825 (International)