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Summary

This webinar explores how diverse mouse models, ranging from conventional inbred strains to genetically engineered and immune-humanized and other xenograft systems, have been used to develop and refine antiviral vaccines.

Taking influenza as our example due to the wealth of literature available, we will consider:

C57BL/6 and BALB/c inbred strains as foundational models in vaccine testing and immunogenicity
Genetically engineered mice expressing humanized receptors or HLA alleles that improve viral entry and antigen presentation
Humanized immune system models, such as immunodeficient NSG mice engrafted with human PBMCs, which enable assessment of human-specific immune responses in situ that inform vaccination strategies.
Future directions in xenograft model development that will provide further insight into tissue-specific human immune responses to this respiratory pathogen.

Broadly, each of these strategies represent a piece of the puzzle of antiviral immunity; we hope our discussion provides a framework for selecting the most appropriate model depending on your specific research goals.

*NSG is a registered trademark in the USA and other countries

JAX^® Webinars are complimentary.
No fees will be charged for registering.

Webinars are 45-50 minutes long, followed by a Q&A session.

When registering, please use an institutional (e.g. work, university, etc.) email address or contact our event staff to request an exception. Thank you.

Mouse Models Shaping Antiviral Vaccine Development

When registering, please use an institutional (e.g. work, university, etc.) email address or contact our event staff to request an exception. Thank you.