Summary
Alzheimer’s disease (AD) is a genetically complex neurodegenerative disorder that poses significant challenges for the development and validation of predictive mouse models for preclinical research.
In this presentation, we will address the following topics:
- Evaluation of widely used traditional AD mouse models, such as 5xFAD and 3xTg, which represent familial AD conditions accounting for less than five percent of Alzheimer’s disease cases
- Discussion of the scientific rationale for the development of next generation models through the MODEL AD consortium, including late onset Alzheimer’s disease (LOAD) models designed to better capture the genetic risk architecture and disease heterogeneity associated with sporadic AD
- Guidance on the informed selection of in vivo mouse models for the preclinical evaluation of therapeutic candidates for Alzheimer’s disease
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