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In Vivo Platforms for Autoimmune Pharmacology: MS-EAE Capabilities

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Experimental Autoimmune Encephalomyelitis (EAE): Leading model for CD4 T-cell-mediated Multiple sclerosis (MS) -SJL Model Study Design T cell dependent model that induces the clinically relevant relapsing-remitting form of the disease observed in ~80% of MS patients -B6J Model, Study Design T cell dependent model that induces the clinically relevant primary progressive form of the disease observed in ~10% of MS patients MS is a chronic autoimmune disease affecting the central nervous system. In MS, the immune system (T cell, macrophages) attacks the protective sheath (myelin) that covers nerve fibers and causes communication problems between brain, spinal cord and the rest of the body.