Event Registration

Summary

Drug developers are now capable of manipulating the human immune system for therapeutic benefit using a wide range of unique cellular and molecular approaches. While inbred mice and in vitro assays provide proof of principle, platforms that support in vivo human immune cell development and function are critical for providing human-specific targets and uncovering the cellular and molecular interactions needed to model both efficacy and safety prior to clinical trials.

Join us for an overview of the immunobiology of humanized mice engrafted with human hematopoietic stem cells (HSCs) and peripheral blood mononuclear cells (PBMCs) and explore examples of how these platforms support preclinical evaluation of a wide range of immuno-oncology therapeutics.

In this webinar, we will explore:

Key differences between PBMC and CD34+ stem cell engraftment
Applications for PBMC and CD34 engrafted mice for immuno-oncology
Comparison of NSG* and NSG-MHC I/II DKO models for studying immune responses

*NSG is a registered trademark in the USA and other countries

JAX™ Webinars are complimentary.
No fees will be charged for registering.

Webinars are 45-50 minutes long, followed by a Q&A session.

When registering, please use an institutional (e.g. work, university, etc.) email address or contact our event staff to request an exception. Thank you.

Human HSC and PBMC Mouse Platforms for In Vivo Immune Modulatory Drug Discovery

When registering, please use an institutional (e.g. work, university, etc.) email address or contact our event staff to request an exception. Thank you.