Topics: Humanized NSG™ Mice for Innovative Preclinical Research & Predictive Cancer Models Using Patient-derived Xenograft Mice 


Winship Cancer Institute, Atlanta
John H. Kauffman Auditorium (C5012, 5th Floor Winship)
Thursday, November 02, 2017
1:00 - 3:00 pm


Whether you are new to using mouse models of disease or a seasoned professional, The Jackson Laboratory has valuable resources to assist you. Join us to learn helpful tips and receive training that will give you the tools you need for your research.


Please fill out the form below to register for the upcoming JAX Seminar. Upon submission a confirmation will be sent to the email address provided.

Agenda


Humanized NSG™ Mice for Innovative Preclinical Research 
1:00 - 2:00 pm

The NOD scid gamma mouse uniquely supports the engraftment of human hematopoietic cells, enabling the creation of “humanized” NSG™ (hu-NSG™) mice. These mice serve as the state-of-the art platform for studying immunobiology, infectious diseases, graft-versus-host disease, and transplantation. Join this seminar to learn about the superior capabilities of the NSG™ mouse and the following topics:
  • Key genetic components rendering NSG™ mice immunodeficient  
  • The superiority of the NSG™ mouse as a platform for humanization
  • Advantages and considerations for specific NSG™ humanization protocols
  • Data demonstrating preclinical applications of hu-NSG™ mice
  • How to obtain humanized NSG™ from JAX® In Vivo Pharmacology Services



Predictive Cancer Models Using Patient-derived Xenograft Mice 
2:00 - 3:00 pm

Patient-derived xenograft (PDX) cancer models show great promise as preclinical models because they recapitulate the heterogeneity of human cancer in a manner that is easily accessible for the research community. The JAX® PDX program was developed in collaboration with renowned cancer hospitals to advance the course of preclinical drug development. In this seminar, you will... 
  • Learn how more than 280 PDX models have been established in partnership with a consortium of cancer hospitals and clinical trial teams 
  • Appreciate how the diversity of the PDX program represents current patient demographics 
  • See how the genetics, pathology, and treatment response of PDX tumors reflect clinical observations  
  • Learn how to search for relevant models and find characterization data using the Mouse Tumor Databases
  • Understand how to obtain PDX models from JAX® In Vivo Pharmacology Services

Snacks
1:00 pm




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